Faktor PTA

Faktor PTA (bahasa Inggris: plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI) adalah zimogen dari jenis serina protease yang merupakan prekursor dari faktor XIa, yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma tromboplastin intrinsik[1] saat darah terpapar oleh permukaan asing.[2] Pada manusia, FXI terkodikasi dalam gen F11.[3][4][5][6]

FXI disintesis oleh hati dan disekresi dalam bentuk homo-dimer yang tidak aktif[7] dengan waktu paruh sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.[8]

Rujukan

  1. ^ (Inggris)"Factors". Farlex free dictionary. Diakses 2010-04-29. 
  2. ^ (Inggris)"Factor XI". Answer.com. Diakses 2010-04-29. 
  3. ^ Fujikawa K, Chung DW, Hendrickson LE, Davie EW (May 1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein". Biochemistry 25 (9): 2417–24. doi:10.1021/bi00357a018. PMID 3636155. 
  4. ^ Asakai R, Davie EW, Chung DW (November 1987). "Organization of the gene for human factor XI". Biochemistry 26 (23): 7221–8. doi:10.1021/bi00397a004. PMID 2827746. 
  5. ^ Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenet. Cell Genet. 52 (1-2): 77–8. doi:10.1159/000132844. PMID 2612218. 
  6. ^ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ (May 1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". Am. J. Hum. Genet. 48 (5): 911–25. PMC 1683054. PMID 1673289. 
  7. ^ Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN (July 2008). "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". J. Biol. Chem. 283 (27): 18655–64. doi:10.1074/jbc.M802275200. PMID 18441012. 
  8. ^ (Inggris)"Factor XI Deficiency". Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel. Diakses 2010-04-29. 

Pranala luar

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Group
PDC
 
Koenzim
AcCoA " CoA " CoQ10 " FAD " NAD+
 
Enzim
EC 1
.1
.1
Dehidrogenase alkohol
.3 HSD " .4 " .5 " .6 " .7 " .8 " .9 " .10 " .11 " .12 " .13 " .14 " .15 " .16 " .17 " .18 " .19 " .20 " .21 " .22 " .23 " .24 " .25 " .26 " .27 LDH " .146 11β-HSD " .196 15-PGDH
 
.2
 
.3
.1 " .2 " .4 GOX " .8 GLO
 
.2
.4
 
.3
.5
.1 SCCR
SQR " QFR
 
.5
.5
.1 ETF-QO
 
.6
.5
.3 NADHD
 
.9
.3
.1 COX
 
.10
.2
.1 " .2 UCCR
 
.11
.1
.1 " .2 " .3 " .4 " .5 " .6 " .7 " .8 TPO
 
.13
 
.14
.13
.n7 2E1
 
.14
.1 2D6
 
.16
.3
 
EC 2
.3
.2
.1 " .2 GGT
 
.4
.1
 
.6
.1
.1 AST " .2 ALT
 
.7
.1-.4
.1
PI3K
.137 " .153 " .154
 
.2
 
.3
.1 " .2 CK
 
.4
 
.6
 
.7
DNA " Taq " Transkriptase " Telomerase
 
.10-.13
.10 TK
.1
 
.2
PTK-6
 
.11 STK
.1 Rsk " .2 PDK " .3 " .4 " .5 " .6 " .7 " .8 " .9 " .10 " .11 " .12 " .13 " .14 " .15 " .16 " DAPK " .18 " .19 " .20 " .21 " .22 CDK " .24 MAPK
 
.12
 
.13
F3 " Strepto
Glikosil
 
EC3
.1
.1
Lipase
.4 EL " .34 LPL " Fosfo
 
.2
 
.3
 
.2
.1
.1 PA " .2 " .3 " .4 " .5 " .6 " .7 " .8 " .9 " .10 " .11 " .12 " .13 " .14 " .15 " .16 " .17 " .18 " .19 " .20 " .21 " .22 α-gal " .23 β-gal " .166 HPA
 
.3
 
.4
.2
.1 CPA " .2 CPB " .3 CPS
 
.11-.19
.11-15
.11
 
.12
.2 CPA " .3 CPB " .7 CPN " .8 CPS " .11 ACP
 
.13
 
.14
 
.15
 
.16-.18
.16
 
.17
.1 CPA " .2 CPB " .3 CPN " .4 CPS " .6 ACP " .9 CPS " .21 PSMA
 
.18
 
.19
 
.21-.24
.21
FVII " FIX " FX " FXI " FXII " FD " PROC " Trombin
 
.22
 
.23
 
.24
 
.5
.1
 
.2
 
.3
ARG
 
.4
 
.5
 
.6
 
.7
 
EC 4
.1
.1
 
.2
 
.3
 
.2
 
.3
.1
 
.2
 
.4
 
.5
 
.6
Pektin
 
EC 5
 
EC 6
DNA
 
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Girase
 
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Lihat pula : Asam amino " Darah " Hormon

Sumber :
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